458d

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(New page: 200px<br /><applet load="458d" size="350" color="white" frame="true" align="right" spinBox="true" caption="458d, resolution 2.3&Aring;" /> '''DNA MINOR-GROOVE RECO...)
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[[Image:458d.gif|left|200px]]<br /><applet load="458d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="458d, resolution 2.3&Aring;" />
 
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'''DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG BY A NON-SELF-COMPLEMENTARY AT-RICH SEQUENCE'''<br />
 
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==Overview==
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==DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG BY A NON-SELF-COMPLEMENTARY AT-RICH SEQUENCE==
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The crystal structure of the non-self-complementary dodecamer DNA duplex, formed by d(CG[5BrC]ATAT-TTGCG) and d(CGCAAATATGCG) has been solved to 2.3, A resolution, together with that of its complex with the, tris-benzimidazole minor groove binding ligand TRIBIZ. The inclusion of a, bromine atom on one strand in each structure enabled the possibility of, disorder to be discounted. The native structure has an exceptional narrow, minor groove, of 2.5-2.6 A in the central part of the A/T region, which is, increased in width by approximately 0.8 A on drug binding. The ligand, molecule binds in the central part of the sequence. The benzimidazole, subunits of the ligand participate in six bifurcated hydrogen bonds with, A:T base pair edges, three to each DNA strand. The presence of a pair of, C-H...O hydrogen bonds has been deduced from the close proximity of the, pyrrolidine group of the ligand to the TpA step in the sequence.
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<StructureSection load='458d' size='340' side='right'caption='[[458d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[458d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=458D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=458D FirstGlance]. <br>
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458D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=458D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=458d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=458d OCA], [https://pdbe.org/458d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=458d RCSB], [https://www.ebi.ac.uk/pdbsum/458d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=458d ProSAT]</span></td></tr>
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DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand., Aymami J, Nunn CM, Neidle S, Nucleic Acids Res. 1999 Jul 1;27(13):2691-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10373586 10373586]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Aymami, J.]]
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</StructureSection>
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[[Category: Neidle, S.]]
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[[Category: Large Structures]]
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[[Category: Nunn, C.M.]]
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[[Category: Aymami J]]
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[[Category: b-dna]]
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[[Category: Neidle S]]
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[[Category: deoxyribonucleic acid]]
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[[Category: Nunn CM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:44:20 2008''
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Current revision

DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG BY A NON-SELF-COMPLEMENTARY AT-RICH SEQUENCE

PDB ID 458d

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