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2bjo

From Proteopedia

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[[Image:2bjo.png|left|200px]]
 
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==Crystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilis==
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The line below this paragraph, containing "STRUCTURE_2bjo", creates the "Structure Box" on the page.
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<StructureSection load='2bjo' size='340' side='right'caption='[[2bjo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bjo OCA], [https://pdbe.org/2bjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bjo RCSB], [https://www.ebi.ac.uk/pdbsum/2bjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bjo ProSAT]</span></td></tr>
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{{STRUCTURE_2bjo| PDB=2bjo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OHRB_BACSU OHRB_BACSU] Involved in organic hydroperoxide resistance.<ref>PMID:11418552</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/2bjo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bjo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the fully oxidized form of the Bacillus subtilis organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A resolution. The electron density reveals an intact catalytic disulfide bond (Cys55-Cys119) in each of the two molecules, which are intertwined into a canonical obligate dimer. However, the stereochemistry of the disulfides is unorthodox and strained, suggesting that they are sensitive to reducing agents. A deep solvent-accessible gorge reaching Cys55 may represent the access route for the reductant.
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===CRYSTAL STRUCTURE OF THE ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN OHRB OF BACILLUS SUBTILIS===
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Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state.,Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:18084074<ref>PMID:18084074</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18084074}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bjo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18084074 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18084074}}
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==About this Structure==
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[[2bjo]] is a 2 chain structure of [[Organic hydroperoxide resistance protein]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA].
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==See Also==
==See Also==
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*[[Organic hydroperoxide resistance protein]]
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*[[Organic hydroperoxide resistance protein|Organic hydroperoxide resistance protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018084074</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Bielnicki, J.]]
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[[Category: Large Structures]]
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[[Category: Cooper, D R.]]
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[[Category: Bielnicki J]]
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[[Category: Derewenda, Z S.]]
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[[Category: Cooper DR]]
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[[Category: Devedjiev, Y.]]
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[[Category: Derewenda ZS]]
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[[Category: Joachimiak, A.]]
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[[Category: Devedjiev Y]]
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[[Category: Surendranath, Y.]]
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[[Category: Joachimiak A]]
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[[Category: Heat shock protein]]
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[[Category: Surendranath Y]]
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[[Category: Organic hydroperoxide resistance]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilis

PDB ID 2bjo

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