2x71

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2x71" [edit=sysop:move=sysop])
Current revision (10:25, 20 December 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2x71.png|left|200px]]
 
-
<!--
+
==Structural basis for the interaction of lactivicins with serine beta- lactamases==
-
The line below this paragraph, containing "STRUCTURE_2x71", creates the "Structure Box" on the page.
+
<StructureSection load='2x71' size='340' side='right'caption='[[2x71]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2x71]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_licheniformis Bacillus licheniformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X71 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=L4C:(2E)-2-{[(2S)-2-(ACETYLAMINO)-2-CARBOXYETHOXY]IMINO}PENTANEDIOIC+ACID'>L4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2x71| PDB=2x71 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x71 OCA], [https://pdbe.org/2x71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x71 RCSB], [https://www.ebi.ac.uk/pdbsum/2x71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x71 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/P94458_BACLI P94458_BACLI]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/2x71_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x71 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Lactivicin (LTV) is a natural non-beta-lactam antibiotic that inhibits penicillin-binding proteins and serine beta-lactamases. A crystal structure of a BS3-LTV complex reveals that, as for its reaction with PBPs, LTV reacts with the nucleophilic serine and that cycloserine and lactone rings of LTV are opened. This structure, together with reported structures of PBP1b with lactivicins, provides a basis for developing improved lactivicin-based gamma-lactam antibiotics.
-
===STRUCTURAL BASIS FOR THE INTERACTION OF LACTIVICINS WITH SERINE BETA-LACTAMASES===
+
Structural Basis for the Interaction of Lactivicins with Serine beta-Lactamases.,Brown T, Charlier P, Herman R, Schofield CJ, Sauvage E J Med Chem. 2010 Jul 1. PMID:20593835<ref>PMID:20593835</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2x71" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20593835}}, adds the Publication Abstract to the page
+
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 20593835 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20593835}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[2x71]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_licheniformis Bacillus licheniformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X71 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:020593835</ref><references group="xtra"/>
+
[[Category: Bacillus licheniformis]]
[[Category: Bacillus licheniformis]]
-
[[Category: Beta-lactamase]]
+
[[Category: Large Structures]]
-
[[Category: Charlier, P.]]
+
[[Category: Charlier P]]
-
[[Category: Herman, R.]]
+
[[Category: Herman R]]
-
[[Category: Kerff, F.]]
+
[[Category: Kerff F]]
-
[[Category: Rocaboy, M.]]
+
[[Category: Rocaboy M]]
-
[[Category: Sauvage, E.]]
+
[[Category: Sauvage E]]
-
[[Category: Antibiotic]]
+
-
[[Category: Hydrolase-antibiotic complex]]
+

Current revision

Structural basis for the interaction of lactivicins with serine beta- lactamases

PDB ID 2x71

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2x71"
Personal tools