2co6

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[[Image:2co6.png|left|200px]]
 
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==Salmonella enterica SafA pilin in complex with the SafB chaperone (Type I)==
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The line below this paragraph, containing "STRUCTURE_2co6", creates the "Structure Box" on the page.
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<StructureSection load='2co6' size='340' side='right'caption='[[2co6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2co6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CO6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2co6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co6 OCA], [https://pdbe.org/2co6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2co6 RCSB], [https://www.ebi.ac.uk/pdbsum/2co6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2co6 ProSAT]</span></td></tr>
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{{STRUCTURE_2co6| PDB=2co6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8ZRK4_SALTY Q8ZRK4_SALTY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2co6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2co6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Gram-negative pathogens commonly use the chaperone-usher pathway to assemble adhesive multisubunit fibers on their surface. In the periplasm, subunits are stabilized by a chaperone that donates a beta strand to complement the subunits' truncated immunoglobulin-like fold. Pilus assembly proceeds through a "donor-strand exchange" (DSE) mechanism whereby this complementary beta strand is replaced by the N-terminal extension (Nte) of an incoming pilus subunit. Using X-ray crystallography and real-time electrospray ionization mass spectrometry (ESI-MS), we demonstrate that DSE requires the formation of a transient ternary complex between the chaperone-subunit complex and the Nte of the next subunit to be assembled. The process is crucially dependent on an initiation site (the P5 pocket) needed to recruit the incoming Nte. The data also suggest a capping reaction displacing DSE toward product formation. These results support a zip-in-zip-out mechanism for DSE and a catalytic role for the usher, the molecular platform at which pili are assembled.
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===SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH THE SAFB CHAPERONE (TYPE I)===
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Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism.,Remaut H, Rose RJ, Hannan TJ, Hultgren SJ, Radford SE, Ashcroft AE, Waksman G Mol Cell. 2006 Jun 23;22(6):831-42. PMID:16793551<ref>PMID:16793551</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2co6" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16793551}}, adds the Publication Abstract to the page
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*[[Pilin 3D structures|Pilin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16793551 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16793551}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2co6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CO6 OCA].
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Ashcroft AE]]
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==Reference==
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[[Category: Hannan TJ]]
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<ref group="xtra">PMID:016793551</ref><references group="xtra"/>
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[[Category: Hultgren SJ]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Radford SE]]
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[[Category: Ashcroft, A E.]]
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[[Category: Remaut H]]
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[[Category: Hannan, T J.]]
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[[Category: Rose RJ]]
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[[Category: Hultgren, S J.]]
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[[Category: Waksman G]]
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[[Category: Radford, S E.]]
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[[Category: Remaut, H.]]
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[[Category: Rose, R J.]]
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[[Category: Waksman, G.]]
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[[Category: Adhesion]]
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[[Category: Chaperone]]
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[[Category: Fibril protein]]
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[[Category: Pathogenesis]]
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[[Category: Pilus subunit]]
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[[Category: Strand complementation]]
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Current revision

Salmonella enterica SafA pilin in complex with the SafB chaperone (Type I)

PDB ID 2co6

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OCA

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