2wcr

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[[Image:2wcr.png|left|200px]]
 
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==Crystal Structure of Tip-Alpha N34 (HP0596) from Helicobacter pylori at pH8==
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The line below this paragraph, containing "STRUCTURE_2wcr", creates the "Structure Box" on the page.
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<StructureSection load='2wcr' size='340' side='right'caption='[[2wcr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wcr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_2wcr| PDB=2wcr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcr OCA], [https://pdbe.org/2wcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wcr RCSB], [https://www.ebi.ac.uk/pdbsum/2wcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O25318_HELPY O25318_HELPY]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori secretes a unique virulence factor, Tipalpha, that enters gastric cells and both stimulates the production of the TNF-alpha and activates the NF-kappaB pathway. The structures of a truncated version of Tipalpha (TipalphaN34) in two crystal forms are presented here. Tipalpha adopts a novel beta(1)alpha(1)alpha(2)beta(2)beta(3)alpha(3)alpha(4) topology that can be described as a combination of three domains. A first region consists in a short flexible extension, a second displays a dodecin-like fold and a third is a helical bundle domain similar to the sterile alpha motif (SAM). Analysis of the oligomerisation states of TipalphaN34 in the crystals and in solution suggests that the disulfide bridges could hold together Tipalpha monomers during their secretion in the gastric environment.
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===CRYSTAL STRUCTURE OF TIP-ALPHA N34 (HP0596) FROM HELICOBACTER PYLORI AT PH8===
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Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori.,Tosi T, Cioci G, Jouravleva K, Dian C, Terradot L FEBS Lett. 2009 May 19;583(10):1581-5. Epub 2009 May 4. PMID:19401200<ref>PMID:19401200</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19401200}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wcr" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19401200 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19401200}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2wcr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCR OCA].
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==Reference==
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<ref group="xtra">PMID:019401200</ref><references group="xtra"/>
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[[Category: Helicobacter pylori]]
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[[Category: Cioci, G.]]
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[[Category: Dian, C.]]
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[[Category: Jouravleva, K.]]
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[[Category: Terradot, L.]]
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[[Category: Tosi, T.]]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Hp0596]]
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[[Category: Large Structures]]
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[[Category: Immune system]]
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[[Category: Cioci G]]
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[[Category: Tip-alpha]]
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[[Category: Dian C]]
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[[Category: Jouravleva K]]
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[[Category: Terradot L]]
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[[Category: Tosi T]]

Current revision

Crystal Structure of Tip-Alpha N34 (HP0596) from Helicobacter pylori at pH8

PDB ID 2wcr

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