3tf2

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'''Unreleased structure'''
 
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The entry 3tf2 is ON HOLD
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==Crystal structure of the cap free human translation initiation factor eIF4E==
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<StructureSection load='3tf2' size='340' side='right'caption='[[3tf2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TF2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tf2 OCA], [https://pdbe.org/3tf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tf2 RCSB], [https://www.ebi.ac.uk/pdbsum/3tf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tf2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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Authors: Siddiqui, N., Tempel, W., Nedyalkova, L., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Borden, K.L.B., Park, H., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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Description: Crystal structure of the cap free human translation initiation factor eIF4E
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Borden KLB]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Nedyalkova L]]
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[[Category: Park H]]
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[[Category: Siddiqui N]]
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[[Category: Tempel W]]
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[[Category: Weigelt J]]
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[[Category: Wernimont AK]]

Current revision

Crystal structure of the cap free human translation initiation factor eIF4E

PDB ID 3tf2

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