3thj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3thj is ON HOLD Authors: D'Antonio, E.L., Christianson, D.W. Description: Crystal structure of the Co2+2-HAI-L-Orn complex) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Co2+2-HAI-L-Orn complex== | |
| + | <StructureSection load='3thj' size='340' side='right'caption='[[3thj]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3thj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3THJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3THJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3thj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3thj OCA], [https://pdbe.org/3thj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3thj RCSB], [https://www.ebi.ac.uk/pdbsum/3thj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3thj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Arginase 3D structures|Arginase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Christianson DW]] | ||
| + | [[Category: D'Antonio EL]] | ||
Current revision
Crystal structure of the Co2+2-HAI-L-Orn complex
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