3t77

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[[Image:3t77.jpg|left|200px]]
 
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==S25-2- A(2-4)KDO disaccharide complex==
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The line below this paragraph, containing "STRUCTURE_3t77", creates the "Structure Box" on the page.
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<StructureSection load='3t77' size='340' side='right'caption='[[3t77]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1q9t 1q9t]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T77 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=KDA:(3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID)-2-O-ALLYL'>KDA</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t77 OCA], [https://pdbe.org/3t77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t77 RCSB], [https://www.ebi.ac.uk/pdbsum/3t77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t77 ProSAT]</span></td></tr>
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{{STRUCTURE_3t77| PDB=3t77 | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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High-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes. The germline response to a carbohydrate immunogen can be critical to survivability, with selection for antibody gene segments that both confer protection against common pathogens and retain the flexibility to adapt to new disease organisms. We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, and provides insight into the link between the genetic origin of individual CDRs and their respective roles in antigen recognition.
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===S25-2- A(2-4)KDO disaccharide complex===
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Germline antibody recognition of distinct carbohydrate epitopes.,Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:14625588<ref>PMID:14625588</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t77" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14625588}}, adds the Publication Abstract to the page
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*[[Antibody 3D structures|Antibody 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14625588 is the PubMed ID number.
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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== References ==
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{{ABSTRACT_PUBMED_14625588}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3t77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1q9t 1q9t]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T77 OCA].
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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==Reference==
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[[Category: Brade, H]]
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<ref group="xtra">PMID:014625588</ref><references group="xtra"/>
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[[Category: Brade, L]]
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[[Category: Mus musculus]]
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[[Category: Evans, S V]]
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[[Category: Brade, H.]]
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[[Category: Kosma, P]]
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[[Category: Brade, L.]]
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[[Category: Mackenzie, C R]]
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[[Category: Evans, S V.]]
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[[Category: Nguyen, H P]]
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[[Category: Kosma, P.]]
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[[Category: Seto, N O]]
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[[Category: Mackenzie, C R.]]
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[[Category: Nguyen, H P.]]
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[[Category: Seto, N O.]]
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[[Category: Anti-carbohydrate]]
[[Category: Anti-carbohydrate]]
[[Category: Anti-lp]]
[[Category: Anti-lp]]

Current revision

S25-2- A(2-4)KDO disaccharide complex

PDB ID 3t77

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