3sie

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:36, 20 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3sie.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors==
-
The line below this paragraph, containing "STRUCTURE_3sie", creates the "Structure Box" on the page.
+
<StructureSection load='3sie' size='340' side='right'caption='[[3sie]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3sie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SIE FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BO:5-BROMO-6-ETHYL-2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}PYRIMIDIN-4(3H)-ONE'>5BO</scene></td></tr>
-
{{STRUCTURE_3sie| PDB=3sie | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sie OCA], [https://pdbe.org/3sie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sie RCSB], [https://www.ebi.ac.uk/pdbsum/3sie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sie ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
-
===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
+
==See Also==
-
 
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21714539}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 21714539 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_21714539}}
+
-
 
+
-
==About this Structure==
+
-
[[3sie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SIE OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021714539</ref><references group="xtra"/>
+
-
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chen, T.]]
+
[[Category: Large Structures]]
-
[[Category: Chen, T T.]]
+
[[Category: Chen T]]
-
[[Category: Xu, Y C.]]
+
[[Category: Chen TT]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
[[Category: Xu YC]]
-
[[Category: Pde5a inhibitor]]
+

Current revision

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB ID 3sie

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3sie"
Personal tools