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3shz

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[[Image:3shz.jpg|left|200px]]
 
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==Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors==
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The line below this paragraph, containing "STRUCTURE_3shz", creates the "Structure Box" on the page.
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<StructureSection load='3shz' size='340' side='right'caption='[[3shz]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3shz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.449&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CO:5-CHLORO-6-ETHYL-2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}PYRIMIDIN-4(3H)-ONE'>5CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3shz| PDB=3shz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shz OCA], [https://pdbe.org/3shz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shz RCSB], [https://www.ebi.ac.uk/pdbsum/3shz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21714539 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21714539}}
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==About this Structure==
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[[3shz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHZ OCA].
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==Reference==
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<ref group="xtra">PMID:021714539</ref><references group="xtra"/>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, T.]]
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[[Category: Large Structures]]
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[[Category: Chen, T T.]]
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[[Category: Chen T]]
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[[Category: Xu, Y C.]]
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[[Category: Chen TT]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Xu YC]]
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[[Category: Pde5a inhibitor]]
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Current revision

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB ID 3shz

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