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3rlg

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[[Image:3rlg.jpg|left|200px]]
 
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==Crystal structure of Loxosceles intermedia phospholipase D isoform 1 H12A mutant==
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The line below this paragraph, containing "STRUCTURE_3rlg", creates the "Structure Box" on the page.
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<StructureSection load='3rlg' size='340' side='right'caption='[[3rlg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rlg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Loxosceles_intermedia Loxosceles intermedia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RLG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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{{STRUCTURE_3rlg| PDB=3rlg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlg OCA], [https://pdbe.org/3rlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlg RCSB], [https://www.ebi.ac.uk/pdbsum/3rlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A1HA_LOXIN A1HA_LOXIN] Catalyzes the hydrolysis of sphingomyelin, lysophosphatidylcholine, and lyso-platelet activating factor but not that of phosphatidylcholine. Shows a high enzymatic activity. Induces dermonecrosis, blood vessel permeability and platelet aggregation (PubMed:9790962). Is directly toxic to kidney (PubMed:16005484) and liver (PubMed:18765244). Also induces hemolysis in a complement-dependent manner (PubMed:9790962) as well as in a complement-independent manner. The hemolysis provoked in a complement-independent manner is composed of several steps. The toxin binds to erythrocyte membranes, hydrolyzes membrane phospholipids (sphingomyelin and lysophosphatidylcholine) thus generating metabolism products that cause hemolysis, probably by provoking an increase of calcium inside cells. The calcium influx is due to the opening of L-type calcium channels, since L-type calcium channel blockers inhibit calcium influx (PubMed:21590705).<ref>PMID:16005484</ref> <ref>PMID:18760322</ref> <ref>PMID:18765244</ref> <ref>PMID:19455508</ref> <ref>PMID:21590705</ref> <ref>PMID:9790962</ref>
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===Crystal structure of Loxosceles intermedia phospholipase D isoform 1 H12A mutant===
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==See Also==
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*[[Phospholipase D 3D structures|Phospholipase D 3D structures]]
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*[[Sphingomyelinase|Sphingomyelinase]]
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== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 21301094 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_21301094}}
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[[Category: Large Structures]]
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==About this Structure==
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[[3rlg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loxosceles_intermedia Loxosceles intermedia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLG OCA].
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==Reference==
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<ref group="xtra">PMID:021301094</ref><references group="xtra"/>
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[[Category: Loxosceles intermedia]]
[[Category: Loxosceles intermedia]]
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[[Category: Sphingomyelin phosphodiesterase D]]
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[[Category: Arni RK]]
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[[Category: Arni, R K.]]
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[[Category: Giuseppe PO]]
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[[Category: Giuseppe, P O.]]
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[[Category: Murakami MT]]
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[[Category: Murakami, M T.]]
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[[Category: Ullah A]]
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[[Category: Ullah, A.]]
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[[Category: Veiga SS]]
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[[Category: Veiga, S S.]]
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[[Category: Hydrolase]]
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[[Category: Inactive mutant h12a phospholipase d]]
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[[Category: Plc-like phosphodiesterase]]
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[[Category: Tim beta/alpha-barrel]]
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Current revision

Crystal structure of Loxosceles intermedia phospholipase D isoform 1 H12A mutant

PDB ID 3rlg

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