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3qdh

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[[Image:3qdh.jpg|left|200px]]
 
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==Crystal structure of Actinomyces fimbrial adhesin FimA==
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The line below this paragraph, containing "STRUCTURE_3qdh", creates the "Structure Box" on the page.
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<StructureSection load='3qdh' size='340' side='right'caption='[[3qdh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qdh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actna Actna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QDH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fimA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1655 ACTNA])</td></tr>
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{{STRUCTURE_3qdh| PDB=3qdh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qdh OCA], [https://pdbe.org/3qdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qdh RCSB], [https://www.ebi.ac.uk/pdbsum/3qdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qdh ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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By combining X-ray crystallography and modelling, we describe here the atomic structure of distinct adhesive moieties of FimA, the shaft fimbrillin of Actinomyces type 2 fimbriae, which uniquely mediates the receptor-dependent intercellular interactions between Actinomyces and oral streptococci as well as host cells during the development of oral biofilms. The FimA adhesin is built with three IgG-like domains, each of which harbours an intramolecular isopeptide bond, previously described in several Gram-positive pilins. Genetic and biochemical studies demonstrate that although these isopeptide bonds are dispensable for fimbrial assembly, cell-cell interactions and biofilm formation, they contribute significantly to the proteolytic stability of FimA. Remarkably, FimA harbours two autonomous adhesive modules, which structurally resemble the Staphylococcus aureus Cna B domain. Each isolated module can bind the plasma glycoprotein asialofetuin as well as the polysaccharide receptors present on the surface of oral streptococci and epithelial cells. Thus, FimA should serve as an excellent paradigm for the development of therapeutic strategies and elucidating the precise molecular mechanisms underlying the interactions between cellular receptors and Gram-positive fimbriae.
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===Crystal structure of Actinomyces fimbrial adhesin FimA===
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Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development.,Mishra A, Devarajan B, Reardon ME, Dwivedi P, Krishnan V, Cisar JO, Das A, Narayana SV, Ton-That H Mol Microbiol. 2011 Jun 23. doi: 10.1111/j.1365-2958.2011.07745.x. PMID:21696465<ref>PMID:21696465</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qdh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21696465 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21696465}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Actna]]
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[[3qdh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomyces_naeslundii Actinomyces naeslundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDH OCA].
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[[Category: Large Structures]]
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[[Category: Devarajan, B]]
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==Reference==
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[[Category: Krishnan, V]]
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<ref group="xtra">PMID:021696465</ref><references group="xtra"/>
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[[Category: Narayana, S V.L]]
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[[Category: Actinomyces naeslundii]]
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[[Category: Devarajan, B.]]
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[[Category: Krishnan, V.]]
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[[Category: Narayana, S V.L.]]
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[[Category: Actinomyces type 2 fimbriae]]
[[Category: Actinomyces type 2 fimbriae]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]

Current revision

Crystal structure of Actinomyces fimbrial adhesin FimA

PDB ID 3qdh

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