3sdl

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[[Image:3sdl.png|left|200px]]
 
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==Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza B virus, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2==
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The line below this paragraph, containing "STRUCTURE_3sdl", creates the "Structure Box" on the page.
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<StructureSection load='3sdl' size='340' side='right'caption='[[3sdl]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sdl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Lee/1940) Influenza B virus (B/Lee/1940)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdl OCA], [https://pdbe.org/3sdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sdl RCSB], [https://www.ebi.ac.uk/pdbsum/3sdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdl ProSAT]</span></td></tr>
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{{STRUCTURE_3sdl| PDB=3sdl | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza B virus, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2===
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[https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21808041 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21808041}}
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==About this Structure==
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[[3sdl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDL OCA].
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==Reference==
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<ref group="xtra">PMID:021808041</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Influenza b virus]]
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[[Category: Large Structures]]
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[[Category: Guan, R.]]
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[[Category: Guan R]]
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[[Category: Krug, R M.]]
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[[Category: Krug RM]]
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[[Category: Ma, L C.]]
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[[Category: Ma L-C]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione GT]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein complex]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Viral protein-antiviral protein complex]]
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[[Category: Viral protein/antiviral protein]]
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Current revision

Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza B virus, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2

PDB ID 3sdl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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