3tik
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one== | |
| + | <StructureSection load='3tik' size='340' side='right'caption='[[3tik]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JKF:6-[(R)-(4-CHLOROPHENYL)(METHOXY)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(2,6-DIFLUOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE'>JKF</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tik OCA], [https://pdbe.org/3tik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tik RCSB], [https://www.ebi.ac.uk/pdbsum/3tik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tik ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q385E8_TRYB2 Q385E8_TRYB2] | ||
| - | + | ==See Also== | |
| - | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma brucei]] | ||
| + | [[Category: Buckner FS]] | ||
| + | [[Category: Gelb MH]] | ||
| + | [[Category: Hargrove TY]] | ||
| + | [[Category: Kraus JM]] | ||
| + | [[Category: Lepesheva GI]] | ||
| + | [[Category: Waterman MR]] | ||
| + | [[Category: Wawrzak Z]] | ||
Current revision
Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one
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