3zyq
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3zyq is ON HOLD Authors: Muniz, J.R.C., Ayinampudi, V., Shrestha, L., Krojer, T., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weige...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the tandem VHS and FYVE domains of Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS-Hrs) at 1.48 A resolution== | |
| - | + | <StructureSection load='3zyq' size='340' side='right'caption='[[3zyq]], [[Resolution|resolution]] 1.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3zyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyq OCA], [https://pdbe.org/3zyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyq RCSB], [https://www.ebi.ac.uk/pdbsum/3zyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HGS_HUMAN HGS_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Ayinampudi V]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bullock A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Muniz JRC]] | ||
| + | [[Category: Shrestha L]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the tandem VHS and FYVE domains of Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS-Hrs) at 1.48 A resolution
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Ayinampudi V | Bountra C | Bullock A | Edwards AM | Krojer T | Muniz JRC | Shrestha L | Vollmar M | Weigelt J | Von Delft F
