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3s2o

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[[Image:3s2o.png|left|200px]]
 
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==Fragment based discovery and optimisation of bace-1 inhibitors==
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The line below this paragraph, containing "STRUCTURE_3s2o", creates the "Structure Box" on the page.
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<StructureSection load='3s2o' size='340' side='right'caption='[[3s2o]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3msm 3msm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S2O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EV6:(3S)-3-(2-AMINO-5-CHLORO-1H-BENZIMIDAZOL-1-YL)-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]PENTANAMIDE'>EV6</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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{{STRUCTURE_3s2o| PDB=3s2o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s2o OCA], [https://pdbe.org/3s2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s2o RCSB], [https://www.ebi.ac.uk/pdbsum/3s2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s2o ProSAT]</span></td></tr>
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</table>
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===Fragment based discovery and optimisation of bace-1 inhibitors===
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 20656487 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20656487}}
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==About this Structure==
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[[3s2o]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3msm 3msm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S2O OCA].
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==See Also==
==See Also==
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*[[Beta secretase]]
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020656487</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Barker, J.]]
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[[Category: Barker J]]
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[[Category: Godemann, R.]]
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[[Category: Godemann R]]
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[[Category: Hallett, D.]]
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[[Category: Hallett D]]
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[[Category: Kraemer, J.]]
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[[Category: Kraemer J]]
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[[Category: Madden, J.]]
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[[Category: Madden J]]
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[[Category: Smith, M A.]]
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[[Category: Smith MA]]
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[[Category: Alzheimer's disease]]
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[[Category: Amyloid precursor protein secretase]]
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[[Category: Aspartic endopeptidase]]
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[[Category: Aspartic protease]]
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[[Category: Aspartyl protease]]
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[[Category: Base]]
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[[Category: Beta-secretase]]
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[[Category: Fluorescence polarisation]]
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[[Category: Fragment-based drug design]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Memapsin 2]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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Current revision

Fragment based discovery and optimisation of bace-1 inhibitors

PDB ID 3s2o

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