3q7c

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[[Image:3q7c.png|left|200px]]
 
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==Exonuclease domain of Lassa virus nucleoprotein bound to manganese==
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The line below this paragraph, containing "STRUCTURE_3q7c", creates the "Structure Box" on the page.
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<StructureSection load='3q7c' size='340' side='right'caption='[[3q7c]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3q7c| PDB=3q7c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7c OCA], [https://pdbe.org/3q7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7c RCSB], [https://www.ebi.ac.uk/pdbsum/3q7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7c ProSAT]</span></td></tr>
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</table>
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===Exonuclease domain of Lassa virus nucleoprotein bound to manganese===
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 21262835 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21262835}}
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==About this Structure==
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[[3q7c]] is a 1 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Lassa_virus Lassa virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7C OCA].
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==See Also==
==See Also==
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*[[Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021262835</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Lassa virus]]
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[[Category: Lassa virus Josiah]]
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[[Category: Hastie, K M.]]
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[[Category: Hastie KM]]
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[[Category: Kimberlin, C R.]]
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[[Category: Kimberlin CR]]
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[[Category: MacRae, I J.]]
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[[Category: MacRae IJ]]
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[[Category: Saphire, E O.]]
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[[Category: Saphire EO]]
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[[Category: Zandonatti, M A.]]
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[[Category: Zandonatti MA]]
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[[Category: 3' exonuclease]]
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[[Category: Arenavirus nucleoprotein]]
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[[Category: Deddh exonuclease]]
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[[Category: Hydrolase]]
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Current revision

Exonuclease domain of Lassa virus nucleoprotein bound to manganese

PDB ID 3q7c

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OCA

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