3tlp

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(New page: '''Unreleased structure''' The entry 3tlp is ON HOLD Authors: Filippakopoulos, P., Felletar, I., Picaud, S., Keates, T., Muniz, J., Krojer, T., Allerston, C.K., Latwiel, S., von Delft, ...)
Current revision (13:33, 14 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3tlp is ON HOLD
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==Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1)==
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<StructureSection load='3tlp' size='340' side='right'caption='[[3tlp]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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Authors: Filippakopoulos, P., Felletar, I., Picaud, S., Keates, T., Muniz, J., Krojer, T., Allerston, C.K., Latwiel, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tlp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TLP FirstGlance]. <br>
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Description: Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tlp OCA], [https://pdbe.org/3tlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tlp RCSB], [https://www.ebi.ac.uk/pdbsum/3tlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tlp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Allerston CK]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Felletar I]]
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[[Category: Filippakopoulos P]]
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[[Category: Keates T]]
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[[Category: Knapp S]]
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[[Category: Krojer T]]
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[[Category: Latwiel S]]
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[[Category: Muniz J]]
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[[Category: Picaud S]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1)

PDB ID 3tlp

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