3p0e

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[[Image:3p0e.jpg|left|200px]]
 
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==Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine==
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The line below this paragraph, containing "STRUCTURE_3p0e", creates the "Structure Box" on the page.
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<StructureSection load='3p0e' size='340' side='right'caption='[[3p0e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p0e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAU:1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE'>BAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3p0e| PDB=3p0e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0e OCA], [https://pdbe.org/3p0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0e RCSB], [https://www.ebi.ac.uk/pdbsum/3p0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UPP2_HUMAN UPP2_HUMAN] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
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===Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine===
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==See Also==
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21855639 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21855639}}
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==About this Structure==
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[[3p0e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0E OCA].
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==Reference==
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<ref group="xtra">PMID:021855639</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Uridine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Castronovo, S.]]
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[[Category: Castronovo S]]
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[[Category: Roosild, T P.]]
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[[Category: Roosild TP]]
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[[Category: Villoso, A.]]
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[[Category: Villoso A]]
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[[Category: Transferase]]
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[[Category: Uridine phosphorylase]]
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Current revision

Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine

PDB ID 3p0e

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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