3sfe

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[[Image:3sfe.jpg|left|200px]]
 
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==crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and thiabendazole==
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The line below this paragraph, containing "STRUCTURE_3sfe", creates the "Structure Box" on the page.
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<StructureSection load='3sfe' size='340' side='right'caption='[[3sfe]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sfe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=TMG:2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE'>TMG</scene></td></tr>
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{{STRUCTURE_3sfe| PDB=3sfe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfe OCA], [https://pdbe.org/3sfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfe RCSB], [https://www.ebi.ac.uk/pdbsum/3sfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SDHA_PIG SDHA_PIG] Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mitochondrial respiratory complex II or succinate: ubiquinone oxidoreductase (SQR) is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration. Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of the porcine mitochondrial SQR by enzymatic assay and crystallography. Crystal structure of the SQR bound with thiabendazole (TBZ) reveals a different inhibitor-binding feature at the ubiquinone binding site where a water molecule plays an important role. The obvious inhibitory effect of TBZ based on the biochemical data (IC(50) approximately 100 mumol/L) and the significant structure-based binding affinity calculation ( approximately 94 mumol/L) draw the suspicion of using TBZ as a good disinfectant compound for nematode infections treatment and fruit storage.
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===crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and thiabendazole===
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Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.,Zhou Q, Zhai Y, Lou J, Liu M, Pang X, Sun F Protein Cell. 2011 Jul;2(7):531-42. Epub 2011 Aug 6. PMID:21822798<ref>PMID:21822798</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3sfe" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21822798}}, adds the Publication Abstract to the page
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*[[Succinate dehydrogenase 3D structures|Succinate dehydrogenase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21822798 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21822798}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3sfe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFE OCA].
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==Reference==
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<ref group="xtra">PMID:021822798</ref><references group="xtra"/>
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Liu, M.]]
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[[Category: Liu M]]
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[[Category: Sun, F.]]
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[[Category: Sun F]]
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[[Category: Zhai, Y J.]]
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[[Category: Zhai YJ]]
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[[Category: Zhou, Q J.]]
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[[Category: Zhou QJ]]
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[[Category: Oxidoreductase]]
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[[Category: Succinate:ubiquinone oxidoreductase]]
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[[Category: Thiabendazole]]
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Current revision

crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and thiabendazole

PDB ID 3sfe

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