3s9c

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[[Image:3s9c.jpg|left|200px]]
 
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==Russell's viper venom serine proteinase, RVV-V in complex with the fragment (residues 1533-1546) of human factor V==
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The line below this paragraph, containing "STRUCTURE_3s9c", creates the "Structure Box" on the page.
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<StructureSection load='3s9c' size='340' side='right'caption='[[3s9c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_siamensis Daboia siamensis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S9C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3s9c| PDB=3s9c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s9c OCA], [https://pdbe.org/3s9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s9c RCSB], [https://www.ebi.ac.uk/pdbsum/3s9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s9c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VSPG_DABSI VSPG_DABSI] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.<ref>PMID:3053712</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Russell's viper venom factor V (FV) activator (RVV-V) is a thrombin-like proteinase that specifically cleaves the Arg1545-Ser1546 bond of FV. Here we present the crystal structure of RVV-V in complex with the FV14 peptide (residues 1533-1546 of human FV) determined at 1.8A resolution. The structure reveals multiple interactions between RVV-V and the seven residues, Ile1539 (P(7))-Arg1545 (P(1)), of the cleaved substrate. Comparison with substrate-free structures reveals conformational changes of the RVV-V loops upon substrate binding, suggesting that the multiple interactions are mediated by an induced-fit mechanism. The results provide an explanation for the narrow specificity of RVV-V.
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===Russell's viper venom serine proteinase, RVV-V in complex with the fragment (residues 1533-1546) of human factor V===
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Structural basis of coagulation factor V recognition for cleavage by RVV-V.,Nakayama D, Ben Ammar Y, Miyata T, Takeda S FEBS Lett. 2011 Aug 23. PMID:21871889<ref>PMID:21871889</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3s9c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21871889 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21871889}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Daboia siamensis]]
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[[3s9c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_siamensis Daboia russellii siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9C OCA].
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Ben Ammar Y]]
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<ref group="xtra">PMID:021871889</ref><ref group="xtra">PMID:020054136</ref><references group="xtra"/>
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[[Category: Nakayama D]]
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[[Category: Daboia russellii siamensis]]
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[[Category: Takeda S]]
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[[Category: Snake venom factor V activator]]
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[[Category: Ammar, Y Ben.]]
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[[Category: Nakayama, D.]]
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[[Category: Takeda, S.]]
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[[Category: Double six-stranded beta-barrel]]
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[[Category: Glycosylation]]
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[[Category: Hydrolase]]
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[[Category: Serine proteinase]]
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Current revision

Russell's viper venom serine proteinase, RVV-V in complex with the fragment (residues 1533-1546) of human factor V

PDB ID 3s9c

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