1gq8

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[[Image:1gq8.png|left|200px]]
 
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==Pectin methylesterase from Carrot==
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The line below this paragraph, containing "STRUCTURE_1gq8", creates the "Structure Box" on the page.
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<StructureSection load='1gq8' size='340' side='right'caption='[[1gq8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daucus_carota Daucus carota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GQ8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1gq8| PDB=1gq8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gq8 OCA], [https://pdbe.org/1gq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1gq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gq8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PME_DAUCA PME_DAUCA] Catalyzes the deesterification of methyl-esterified D-galactosiduronic acid units in pectic compounds. It participates in modulating cell wall during fruit ripening, cell wall extension during pollen germination, and in defense mechanisms against pathogens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/1gq8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gq8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pectin is a principal component in the primary cell wall of plants. During cell development, pectin is modified by pectin methylesterases to give different properties to the cell wall. This report describes the first crystal structure of a plant pectin methylesterase. The beta-helical structure embodies a central cleft, lined by several aromatic residues, that has been deduced to be suitable for pectin binding. The active site is found at the center of this cleft where Asp157 is suggested to act as the nucleophile, Asp136 as an acid/base and Gln113/Gln135 to form an anion hole to stabilize the transition state.
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===PECTIN METHYLESTERASE FROM CARROT===
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Crystal structure of plant pectin methylesterase.,Johansson K, El-Ahmad M, Friemann R, Jornvall H, Markovic O, Eklund H FEBS Lett. 2002 Mar 13;514(2-3):243-9. PMID:11943159<ref>PMID:11943159</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1gq8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11943159}}, adds the Publication Abstract to the page
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*[[Methylesterase 3D structures|Methylesterase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11943159 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11943159}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1gq8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Daucus_carota Daucus carota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ8 OCA].
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==Reference==
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<ref group="xtra">PMID:011943159</ref><references group="xtra"/>
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[[Category: Daucus carota]]
[[Category: Daucus carota]]
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[[Category: Pectinesterase]]
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[[Category: Large Structures]]
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[[Category: Eklund, H.]]
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[[Category: Eklund H]]
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[[Category: El-Ahmad, M.]]
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[[Category: El-Ahmad M]]
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[[Category: Friemann, R.]]
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[[Category: Friemann R]]
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[[Category: Johansson, K.]]
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[[Category: Johansson K]]
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[[Category: Jornvall, H.]]
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[[Category: Jornvall H]]
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[[Category: Markovic, O.]]
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[[Category: Markovic O]]
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[[Category: Carboxylic ester hydrolase]]
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[[Category: Hydrolase]]
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Current revision

Pectin methylesterase from Carrot

PDB ID 1gq8

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