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3zyn

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'''Unreleased structure'''
 
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The entry 3zyn is ON HOLD until Paper Publication
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==Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3==
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<StructureSection load='3zyn' size='340' side='right'caption='[[3zyn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyn OCA], [https://pdbe.org/3zyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyn RCSB], [https://www.ebi.ac.uk/pdbsum/3zyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LRC4B_MOUSE LRC4B_MOUSE] Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3. Cognate NetrinG-NGL interactions depend on three specificity-conferring NetrinG loops, clasped tightly by matching NGL surfaces. We engineered these NGL surfaces to implant custom-made affinities for NetrinG1 and NetrinG2. In a cellular patterning assay, we demonstrate that NetrinG-binding selectivity can direct the sorting of a mixed population of NGLs into discrete cell surface subdomains. These results provide a molecular model for selectivity-based patterning in a neuronal recognition system, dysregulation of which is associated with severe neuropsychological disorders.
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Authors: Seiradake, E., Coles, C.H., Perestenko, P.V., Harlos, K., McIlhinney, R.A.J., Aricescu, A.R., Jones, E.Y.
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Structural basis for cell surface patterning through NetrinG-NGL interactions.,Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.346. PMID:21946559<ref>PMID:21946559</ref>
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Description: Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zyn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Aricescu AR]]
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[[Category: Coles CH]]
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[[Category: Harlos K]]
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[[Category: Jones EY]]
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[[Category: McIlhinney RAJ]]
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[[Category: Perestenko PV]]
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[[Category: Seiradake E]]

Current revision

Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3

PDB ID 3zyn

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