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| - | [[Image:3qyx.jpg|left|200px]] | |
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| - | <!--
| + | ==Crystal structure of Mycobacterium tuberculosis EspR in complex with a small DNA fragment== |
| - | The line below this paragraph, containing "STRUCTURE_3qyx", creates the "Structure Box" on the page.
| + | <StructureSection load='3qyx' size='340' side='right'caption='[[3qyx]], [[Resolution|resolution]] 3.75Å' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[3qyx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYX FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.75Å</td></tr> |
| - | -->
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyx OCA], [https://pdbe.org/3qyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyx RCSB], [https://www.ebi.ac.uk/pdbsum/3qyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyx ProSAT]</span></td></tr> |
| - | {{STRUCTURE_3qyx| PDB=3qyx | SCENE= }}
| + | </table> |
| - | | + | == Function == |
| - | ===Crystal structure of Mycobacterium tuberculosis EspR in complex with a small DNA fragment===
| + | [https://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref> |
| - | | + | == References == |
| - | | + | <references/> |
| - | <!-- | + | __TOC__ |
| - | The line below this paragraph, {{ABSTRACT_PUBMED_21883526}}, adds the Publication Abstract to the page
| + | </StructureSection> |
| - | (as it appears on PubMed at http://www.pubmed.gov), where 21883526 is the PubMed ID number.
| + | [[Category: Large Structures]] |
| - | -->
| + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | {{ABSTRACT_PUBMED_21883526}}
| + | [[Category: Blasco B]] |
| - | | + | [[Category: Cole ST]] |
| - | ==About this Structure== | + | [[Category: Pojer F]] |
| - | [[3qyx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYX OCA]. | + | |
| - | | + | |
| - | ==Reference== | + | |
| - | <ref group="xtra">PMID:021883526</ref><references group="xtra"/> | + | |
| - | [[Category: Mycobacterium tuberculosis]] | + | |
| - | [[Category: Blasco, B.]]
| + | |
| - | [[Category: Cole, S T.]] | + | |
| - | [[Category: Pojer, F.]] | + | |
| - | [[Category: C-terminal dimerization domain]] | + | |
| - | [[Category: Dimer of dimers binding dna]] | + | |
| - | [[Category: Dna-binding]] | + | |
| - | [[Category: N-terminal hth motif]] | + | |
| - | [[Category: Transcription activator]] | + | |
| - | [[Category: Transcription factor]] | + | |
| - | [[Category: Transcription-dna complex]] | + | |
| Structural highlights
Function
ESPR_MYCTU Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.[1] [2] [3] [4]
References
- ↑ Raghavan S, Manzanillo P, Chan K, Dovey C, Cox JS. Secreted transcription factor controls Mycobacterium tuberculosis virulence. Nature. 2008 Aug 7;454(7205):717-21. doi: 10.1038/nature07219. PMID:18685700 doi:http://dx.doi.org/10.1038/nature07219
- ↑ Hunt DM, Sweeney NP, Mori L, Whalan RH, Comas I, Norman L, Cortes T, Arnvig KB, Davis EO, Stapleton MR, Green J, Buxton RS. Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis. J Bacteriol. 2012 May;194(9):2307-20. doi: 10.1128/JB.00142-12. Epub 2012 Mar 2. PMID:22389481 doi:http://dx.doi.org/10.1128/JB.00142-12
- ↑ Blasco B, Chen JM, Hartkoorn R, Sala C, Uplekar S, Rougemont J, Pojer F, Cole ST. Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein. PLoS Pathog. 2012;8(3):e1002621. doi: 10.1371/journal.ppat.1002621. Epub 2012 Mar, 29. PMID:22479184 doi:http://dx.doi.org/10.1371/journal.ppat.1002621
- ↑ Blasco B, Stenta M, Alonso-Sarduy L, Dietler G, Peraro MD, Cole ST, Pojer F. Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis. Mol Microbiol. 2011 Aug 30. doi: 10.1111/j.1365-2958.2011.07813.x. PMID:21883526 doi:10.1111/j.1365-2958.2011.07813.x
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