3r3l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:09, 14 March 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3r3l.jpg|left|200px]]
 
-
<!--
+
==Structure of NP protein from Lassa AV strain==
-
The line below this paragraph, containing "STRUCTURE_3r3l", creates the "Structure Box" on the page.
+
<StructureSection load='3r3l' size='340' side='right'caption='[[3r3l]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3r3l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_mammarenavirus Lassa mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R3L FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.449&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_3r3l| PDB=3r3l | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r3l OCA], [https://pdbe.org/3r3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r3l RCSB], [https://www.ebi.ac.uk/pdbsum/3r3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r3l ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9DQX7_LASV Q9DQX7_LASV] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and therby participates in the suppression of interferon induction.[HAMAP-Rule:MF_04085]
-
===Structure of NP protein from Lassa AV strain===
+
==See Also==
-
 
+
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[3r3l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus Lassa virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R3L OCA].
+
[[Category: Large Structures]]
-
[[Category: Lassa virus]]
+
[[Category: Lassa mammarenavirus]]
-
[[Category: Betzel, C.]]
+
[[Category: Betzel C]]
-
[[Category: Brunotte, L.]]
+
[[Category: Brunotte L]]
-
[[Category: Gunther, S.]]
+
[[Category: Gunther S]]
-
[[Category: Perbandt, M.]]
+
[[Category: Perbandt M]]
-
[[Category: Nuclear protein]]
+
-
[[Category: Replication]]
+
-
[[Category: Structural protein]]
+
-
[[Category: Viral protein]]
+

Current revision

Structure of NP protein from Lassa AV strain

PDB ID 3r3l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3r3l"
Personal tools