3ro5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:44, 1 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ro5.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of influenza A virus nucleoprotein with ligand==
-
The line below this paragraph, containing "STRUCTURE_3ro5", creates the "Structure Box" on the page.
+
<StructureSection load='3ro5' size='340' side='right'caption='[[3ro5]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ro5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Wilson-Smith/1933(H1N1)) Influenza A virus (A/Wilson-Smith/1933(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO5 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LGH:[4-(2-CHLORO-4-NITROPHENYL)PIPERAZIN-1-YL][3-(2-METHOXYPHENYL)-5-METHYL-1,2-OXAZOL-4-YL]METHANONE'>LGH</scene></td></tr>
-
{{STRUCTURE_3ro5| PDB=3ro5 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro5 OCA], [https://pdbe.org/3ro5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro5 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280]
-
===Crystal structure of influenza A virus nucleoprotein with ligand===
+
==See Also==
-
 
+
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[3ro5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO5 OCA].
+
[[Category: Large Structures]]
-
[[Category: Influenza a virus]]
+
[[Category: Baldwin ET]]
-
[[Category: Baldwin, E T.]]
+
[[Category: Edavettal S]]
-
[[Category: Edavettal, S.]]
+
[[Category: Kiefersauer R]]
-
[[Category: Kiefersauer, R.]]
+
[[Category: Langley DR]]
-
[[Category: Langley, D R.]]
+
[[Category: Lewis HA]]
-
[[Category: Lewis, H A.]]
+
[[Category: Maskos K]]
-
[[Category: Maskos, K.]]
+
[[Category: McDonnell PA]]
-
[[Category: McDonnell, P A.]]
+
[[Category: Mortl M]]
-
[[Category: Mortl, M.]]
+
[[Category: Pearce BC]]
-
[[Category: Pearce, B C.]]
+
[[Category: Steinbacher S]]
-
[[Category: Steinbacher, S.]]
+
-
[[Category: Influenza nucleoprotein]]
+
-
[[Category: Viral protein]]
+

Current revision

Crystal structure of influenza A virus nucleoprotein with ligand

PDB ID 3ro5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ro5"
Personal tools