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3rd2

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[[Image:3rd2.png|left|200px]]
 
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==NIP45 SUMO-like Domain 2==
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The line below this paragraph, containing "STRUCTURE_3rd2", creates the "Structure Box" on the page.
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<StructureSection load='3rd2' size='340' side='right'caption='[[3rd2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd2 OCA], [https://pdbe.org/3rd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd2 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd2 ProSAT]</span></td></tr>
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{{STRUCTURE_3rd2| PDB=3rd2 | SCENE= }}
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</table>
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== Function ==
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===NIP45 SUMO-like Domain 2===
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[https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21444718 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21444718}}
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==About this Structure==
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[[3rd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD2 OCA].
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==Reference==
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<ref group="xtra">PMID:021444718</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arvai, A S.]]
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[[Category: Large Structures]]
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[[Category: Perry, J J.P.]]
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[[Category: Arvai AS]]
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[[Category: Tainer, J A.]]
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[[Category: Perry JJP]]
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[[Category: Protein:protein interaction]]
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[[Category: Tainer JA]]
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[[Category: Sumo-like domain 2]]
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[[Category: Transcription]]
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[[Category: Ubc9]]
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Current revision

NIP45 SUMO-like Domain 2

PDB ID 3rd2

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OCA

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