3tq6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3tq6 is ON HOLD Authors: Rubio-Cosials, A., Sydow, J. F., Jimenez-Menendez, N., Fernandez-Millan, P., Montoya, J., Jacobs, H.T., Coll, M., Bernado, ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP== | |
| - | + | <StructureSection load='3tq6' size='340' side='right'caption='[[3tq6]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3tq6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQ6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tq6 OCA], [https://pdbe.org/3tq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tq6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tq6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bernado P]] | ||
| + | [[Category: Coll M]] | ||
| + | [[Category: Fernandez-Millan P]] | ||
| + | [[Category: Jacobs HT]] | ||
| + | [[Category: Jimenez-Menendez N]] | ||
| + | [[Category: Montoya J]] | ||
| + | [[Category: Rubio-Cosials A]] | ||
| + | [[Category: Sola M]] | ||
| + | [[Category: Sydow JF]] | ||
Current revision
Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP
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