3tq8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3tq8 is ON HOLD Authors: Franklin, M.C., Cassidy, M., Hillerich, B., Love, J. Description: Structure of the dihydrofolate reductase (folA) from Cox...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim== | |
| + | <StructureSection load='3tq8' size='340' side='right'caption='[[3tq8]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxiella_burnetii Coxiella burnetii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQ8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tq8 OCA], [https://pdbe.org/3tq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tq8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tq8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q83AB2_COXBU Q83AB2_COXBU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194] | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Coxiella burnetii]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cassidy M]] | ||
| + | [[Category: Franklin MC]] | ||
| + | [[Category: Hillerich B]] | ||
| + | [[Category: Love J]] | ||
Current revision
Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim
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