3pov

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[[Image:3pov.jpg|left|200px]]
 
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==Crystal structure of a SOX-DNA complex==
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The line below this paragraph, containing "STRUCTURE_3pov", creates the "Structure Box" on the page.
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<StructureSection load='3pov' size='340' side='right'caption='[[3pov]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pov]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_8_type_M Human herpesvirus 8 type M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3pov| PDB=3pov | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pov OCA], [https://pdbe.org/3pov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pov RCSB], [https://www.ebi.ac.uk/pdbsum/3pov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pov ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P88925_HHV8 P88925_HHV8]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The early lytic phase of Kaposi's sarcoma herpesvirus infection is characterized by viral replication and the global degradation (shutoff) of host mRNA. Key to both activities is the virally encoded alkaline exonuclease KSHV SOX. While the DNase activity of KSHV SOX is required for the resolution of viral genomic DNA as a precursor to encapsidation, its exact involvement in host shutoff remains to be determined. We present the first crystal structure of a KSHV SOX-DNA complex that has illuminated the catalytic mechanism underpinning both its endo and exonuclease activities. We further illustrate that KSHV SOX, similar to its Epstein-Barr virus homologue, has an intrinsic RNase activity in vitro that although an element of host shutoff, cannot solely account for the phenomenon.
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===Crystal structure of a SOX-DNA complex===
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Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.,Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE Nucleic Acids Res. 2011 Jul;39(13):5744-56. Epub 2011 Mar 17. PMID:21421561<ref>PMID:21421561</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pov" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21421561}}, adds the Publication Abstract to the page
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21421561 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21421561}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human herpesvirus 8 type M]]
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[[3pov]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8_type_m Human herpesvirus 8 type m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POV OCA].
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[[Category: Large Structures]]
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[[Category: Bagneris C]]
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==Reference==
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[[Category: Barrett TE]]
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<ref group="xtra">PMID:021421561</ref><references group="xtra"/>
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[[Category: Human herpesvirus 8 type m]]
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[[Category: Bagneris, C.]]
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[[Category: Barrett, T E.]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Nuclease]]
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[[Category: Nucleus/cytoplasm]]
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[[Category: Type ii restriction endonuclease superfamily]]
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Current revision

Crystal structure of a SOX-DNA complex

PDB ID 3pov

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OCA

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