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1e8k

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[[Image:1e8k.gif|left|200px]]<br /><applet load="1e8k" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1e8k, resolution 1.90&Aring;" />
 
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'''CYCLOPHILIN 3 COMPLEXED WITH DIPEPTIDE ALA-PRO'''<br />
 
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==About this Structure==
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==Cyclophilin 3 Complexed With Dipeptide Ala-Pro==
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1E8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with <scene name='pdbligand=ALA:'>ALA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=CBS:Cyclosporin+Binding+Site'>CBS</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8K OCA].
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<StructureSection load='1e8k' size='340' side='right'caption='[[1e8k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1e8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8k OCA], [https://pdbe.org/1e8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8k RCSB], [https://www.ebi.ac.uk/pdbsum/1e8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYP3_CAEEL CYP3_CAEEL] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e8k ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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The First Direct Determination of a Ligand Binding Constant in Protein Crystals., Wu Sy S, Dornan J, Kontopidis G, Taylor P, Walkinshaw MD, Angew Chem Int Ed Engl. 2001 Feb 2;40(3):582-586. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11180378 11180378]
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dornan, J.]]
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[[Category: Dornan J]]
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[[Category: Kontopidis, G.]]
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[[Category: Kontopidis G]]
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[[Category: Taylor, P.]]
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[[Category: Taylor P]]
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[[Category: Walkinshaw, M.D.]]
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[[Category: Walkinshaw MD]]
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[[Category: Wu, S.Y.]]
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[[Category: Wu SY]]
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[[Category: ALA]]
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[[Category: isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:38:15 2008''
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Current revision

Cyclophilin 3 Complexed With Dipeptide Ala-Pro

PDB ID 1e8k

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