This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3zvr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:14, 20 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3zvr.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of Dynamin==
-
The line below this paragraph, containing "STRUCTURE_3zvr", creates the "Structure Box" on the page.
+
<StructureSection load='3zvr' size='340' side='right'caption='[[3zvr]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3zvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
-
{{STRUCTURE_3zvr| PDB=3zvr | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvr OCA], [https://pdbe.org/3zvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvr RCSB], [https://www.ebi.ac.uk/pdbsum/3zvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DYN1_RAT DYN1_RAT] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Dynamin-related proteins (DRPs) are multi-domain GTPases that function via oligomerization and GTP-dependent conformational changes to play central roles in regulating membrane structure across phylogenetic kingdoms. How DRPs harness self-assembly and GTP-dependent conformational changes to remodel membranes is not understood. Here we present the crystal structure of an assembly-deficient mammalian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state. The dynamin 1 monomer is an extended structure with the GTPase domain and bundle signalling element positioned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its opposing end. Dynamin 1 dimer and higher order dimer multimers form via interfaces located in the stalk. Analysis of these interfaces provides insight into DRP family member specificity and regulation and provides a framework for understanding the biogenesis of higher order DRP structures and the mechanism of DRP-mediated membrane scission events.
-
===CRYSTAL STRUCTURE OF DYNAMIN===
+
The crystal structure of dynamin.,Ford MG, Jenni S, Nunnari J Nature. 2011 Sep 18. doi: 10.1038/nature10441. PMID:21927001<ref>PMID:21927001</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
[[3zvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVR OCA].
+
<div class="pdbe-citations 3zvr" style="background-color:#fffaf0;"></div>
-
[[Category: Dynamin GTPase]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Ford, M G.J.]]
+
[[Category: Ford MGJ]]
-
[[Category: Jenni, S.]]
+
[[Category: Jenni S]]
-
[[Category: Nunnari, J.]]
+
[[Category: Nunnari J]]
-
[[Category: Bse]]
+
-
[[Category: Drp]]
+
-
[[Category: Drp1]]
+
-
[[Category: Endocytosis]]
+
-
[[Category: Gtpase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Membrane fission]]
+
-
[[Category: Mitochondrial fission]]
+
-
[[Category: Ph]]
+
-
[[Category: Stalk]]
+

Current revision

Crystal structure of Dynamin

PDB ID 3zvr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zvr"
Personal tools