Colicin I receptor

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<StructureSection load='2hdi' size='350' side='right' caption='E. coli colicin I receptor (cyan) complexed with colicin Ia receptor-binding domain (green) and lauryl dimethylamine oxide (PDB entry [[2hdi]])' scene='46/466463/Cv/1'>
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{{STRUCTURE_2hdi| PDB=2hdi | SIZE=400| SCENE= |right|CAPTION=E. coli colicin I receptor complexed with colicin Ia receptor-binding domain, [[2hdi]] }}
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'''Colicin I receptor''' (Cir) is an E. coli outer membrane protein which binds colicin Ia. Upon binding it changes its conformation enabling the colicin to insert into the inner membrane forming a voltage-dependent ion channel resulting in killing the bacteria.
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== Function ==
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'''Colicin I receptor''' (Cir) is a TonB-dependent transporter of E. coli outer membrane transports Fe+3 bound to catecholates. Cir is used by [[Colicin|colicin]] Ia to penetrate the cell. Upon binding to colicin Ia Cir changes its conformation enabling the colicin to insert into the inner membrane forming a voltage-dependent ion channel resulting in killing the bacteria.
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== Structural highlights ==
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Cir contains an N-terminal <scene name='46/466463/Cv/2'>plug domain</scene> inserted inside a <scene name='46/466463/Cv/5'>22-stranded transmembrane β barrel</scene>. The <scene name='46/466463/Cv/6'>colicin Ia R domain</scene> interacts with Cir plug domain.<ref>PMID:17464289</ref>
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__NOTOC__
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</StructureSection>
== 3D Structures of Colicin I receptor ==
== 3D Structures of Colicin I receptor ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[2hdf]] – EcCir – ''Escherichia coli''<br />
[[2hdf]] – EcCir – ''Escherichia coli''<br />
[[2hdi]] – EcCir + colicin Ia receptor-binding domain
[[2hdi]] – EcCir + colicin Ia receptor-binding domain
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli colicin I receptor (cyan) complexed with colicin Ia receptor-binding domain (green) and lauryl dimethylamine oxide (PDB entry 2hdi)

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3D Structures of Colicin I receptor

Updated on 18-February-2019

2hdf – EcCir – Escherichia coli
2hdi – EcCir + colicin Ia receptor-binding domain

References

  1. ↑ Buchanan SK, Lukacik P, Grizot S, Ghirlando R, Ali MM, Barnard TJ, Jakes KS, Kienker PK, Esser L. Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import. EMBO J. 2007 May 16;26(10):2594-604. Epub 2007 Apr 26. PMID:17464289

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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