3hug

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[[Image:3hug.png|left|200px]]
 
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==Crystal structure of Mycobacterium tuberculosis anti-sigma factor RslA in complex with -35 promoter binding domain of sigL==
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The line below this paragraph, containing "STRUCTURE_3hug", creates the "Structure Box" on the page.
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<StructureSection load='3hug' size='340' side='right'caption='[[3hug]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hug]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HUG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3hug| PDB=3hug | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hug OCA], [https://pdbe.org/3hug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hug RCSB], [https://www.ebi.ac.uk/pdbsum/3hug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hug ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIGL_MYCTU SIGL_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis. Over-expression of SigL induces 19-28 genes including polyketide synthases, secreted and membrane proteins. Might play a minor role in regulating SigB.<ref>PMID:16199577</ref> <ref>PMID:16552079</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/3hug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hug ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Mycobacterium tuberculosis anti-sigma factor RslA in complex with -35 promoter binding domain of sigL===
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==See Also==
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20184899}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20184899 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20184899}}
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Gopal B]]
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==About this Structure==
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[[Category: Thakur KG]]
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[[3hug]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HUG OCA].
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==Reference==
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<ref group="xtra">PMID:020184899</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Gopal, B.]]
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[[Category: Thakur, K G.]]
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[[Category: Dna binding]]
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[[Category: Dna-binding]]
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[[Category: Ecf sigma factor]]
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[[Category: Hxxxcxxc motif]]
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[[Category: Metal binding]]
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[[Category: Oxidative stress]]
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[[Category: Sigma factor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-membrane protein complex]]
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[[Category: Zinc binding anti-sigma factor]]
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Current revision

Crystal structure of Mycobacterium tuberculosis anti-sigma factor RslA in complex with -35 promoter binding domain of sigL

PDB ID 3hug

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