3qy9

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[[Image:3qy9.png|left|200px]]
 
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==The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus==
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<StructureSection load='3qy9' size='340' side='right'caption='[[3qy9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qy9| PDB=3qy9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [https://pdbe.org/3qy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAPB_STAAC DAPB_STAAC] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lysine biosynthesis proceeds by the nucleotide-dependent reduction of dihydrodipicolinate (DHDP) to tetrahydrodipicolinate (THDP) by dihydrodipicolinate reductase (DHDPR). The S. aureus DHDPR structure reveals different conformational states of this enzyme even in the absence of a substrate or nucleotide-cofactor. Despite lacking a conserved basic residue essential for NADPH interaction, S. aureus DHDPR differs from other homologues as NADPH is a more preferred co-factor than NADH. The structure provides a rationale-Lys35 compensates for the co-factor site mutation. These observations are significant for bi-ligand inhibitor design that relies on ligand-induced conformational changes as well as co-factor specificity for this important drug target. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: DHDPRbindstoDHDPR by molecular sieving(View interaction). DHDPRbindstoDHDPR by dynamic light scattering(View interaction). DHDPRbindstoDHDPR by X-ray crystallography(View interaction).
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===The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus===
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Structure and nucleotide specificity of Staphylococcus aureus dihydrodipicolinate reductase (DapB).,Girish TS, Navratna V, Gopal B FEBS Lett. 2011 Aug 19;585(16):2561-7. Epub 2011 Jul 26. PMID:21803042<ref>PMID:21803042</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qy9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21803042 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21803042}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA].
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[[Category: Staphylococcus aureus subsp. aureus COL]]
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[[Category: Girish TS]]
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==Reference==
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[[Category: Gopal B]]
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<ref group="xtra">PMID:021803042</ref><references group="xtra"/>
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[[Category: Dihydrodipicolinate reductase]]
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[[Category: Staphylococcus aureus]]
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[[Category: Girish, T S.]]
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[[Category: Gopal, B.]]
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[[Category: Dihydrodipicolinate]]
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[[Category: Nadh]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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[[Category: Reductase]]
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[[Category: Rossmann fold]]
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Current revision

The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus

PDB ID 3qy9

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