2l6u

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[[Image:2l6u.png|left|200px]]
 
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==Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of Human Mediator Subuniti 25. Northeast Structural Genomics Consortium Target HR6188A==
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The line below this paragraph, containing "STRUCTURE_2l6u", creates the "Structure Box" on the page.
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<StructureSection load='2l6u' size='340' side='right'caption='[[2l6u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6u OCA], [https://pdbe.org/2l6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6u RCSB], [https://www.ebi.ac.uk/pdbsum/2l6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6u ProSAT]</span></td></tr>
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{{STRUCTURE_2l6u| PDB=2l6u | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Charcot-Marie-Tooth disease type 2B2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19290556</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<ref>PMID:14657022</ref> <ref>PMID:14983011</ref> <ref>PMID:17641689</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution NMR structure of protein MED25(391-543), comprising the activator interacting domain (ACID) of subunit 25 of the human mediator, is presented along with the measurement of polypeptide backbone heteronuclear (15)N-{(1)H} NOEs to identify fast internal motional modes. This domain interacts with the acidic transactivation domains of Herpes simplex type 1 (HSV-1) protein VP16 and the Varicella-zoster virus (VZV) major transactivator protein IE62, which initiate transcription of viral genes. The structure is similar to the beta-barrel domains of the human protein Ku and the SPOC domain of human protein SHARP, and provides a starting point to understand the structural biology of initiation of HSV-1 and VZV gene activation. Homology models built for the two ACID domains of the prostate tumor overexpressed (PTOV1) protein using the structure of MED25(391-543) as a template suggest that differential biological activities of the ACID domains in MED25 and PTOV1 arise from modulation of quite similar protein-protein interactions by variable residues grouped around highly conserved charged surface areas.
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===Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of Human Mediator Subuniti 25. Northeast Structural Genomics Consortium Target HR6188A===
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Solution NMR structure of MED25(391-543) comprising the activator-interacting domain (ACID) of human mediator subunit 25.,Eletsky A, Ruyechan WT, Xiao R, Acton TB, Montelione GT, Szyperski T J Struct Funct Genomics. 2011 Sep;12(3):159-66. Epub 2011 Jul 23. PMID:21785987<ref>PMID:21785987</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l6u" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21785987}}, adds the Publication Abstract to the page
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*[[Mediator|Mediator]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21785987 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21785987}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2l6u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6U OCA].
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==Reference==
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<ref group="xtra">PMID:021785987</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton TB]]
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[[Category: Eletsky, A.]]
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[[Category: Ciccosanti C]]
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[[Category: Everett, J K.]]
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[[Category: Eletsky A]]
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[[Category: Janjua, H.]]
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[[Category: Everett JK]]
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[[Category: Montelione, G T.]]
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[[Category: Janjua H]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Ryuechan, W T.]]
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[[Category: Ryuechan WT]]
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[[Category: Shastry, R.]]
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[[Category: Shastry R]]
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[[Category: Sukumaran, D K.]]
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[[Category: Sukumaran DK]]
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[[Category: Szyperski, T.]]
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[[Category: Szyperski T]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Acid]]
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[[Category: Arc92]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Ptov]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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Current revision

Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of Human Mediator Subuniti 25. Northeast Structural Genomics Consortium Target HR6188A

PDB ID 2l6u

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