3pux

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[[Image:3pux.png|left|200px]]
 
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==Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3==
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The line below this paragraph, containing "STRUCTURE_3pux", creates the "Structure Box" on the page.
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<StructureSection load='3pux' size='340' side='right'caption='[[3pux]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pux]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
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{{STRUCTURE_3pux| PDB=3pux | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pux OCA], [https://pdbe.org/3pux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pux RCSB], [https://www.ebi.ac.uk/pdbsum/3pux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pux ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ATP-binding cassette transporters are powered by ATP, but the mechanism by which these transporters hydrolyze ATP is unclear. In this study, four crystal structures of the full-length wild-type maltose transporter, stabilized by adenosine 5'-(beta,gamma-imido)triphosphate or ADP in conjunction with phosphate analogs , , or , were determined to 2.2- to 2.4-A resolution. These structures led to the assignment of two enzymatic states during ATP hydrolysis and demonstrate specific functional roles of highly conserved residues in the nucleotide-binding domain, suggesting that ATP-binding cassette transporters catalyze ATP hydrolysis via a general base mechanism.
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===Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3===
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Snapshots of the maltose transporter during ATP hydrolysis.,Oldham ML, Chen J Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825153<ref>PMID:21825153</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pux" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21825153 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21825153}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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[[3pux]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUX OCA].
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[[Category: Large Structures]]
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[[Category: Chen J]]
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==Reference==
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[[Category: Oldham ML]]
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<ref group="xtra">PMID:021825153</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
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[[Category: Maltose-transporting ATPase]]
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[[Category: Chen, J.]]
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[[Category: Oldham, M L.]]
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[[Category: Abc transporter]]
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[[Category: Atp binding]]
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[[Category: Atp binding cassette]]
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[[Category: Atpase]]
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[[Category: Hydrolase-transport protein complex]]
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[[Category: Importer]]
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[[Category: Maltodextrin binding]]
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[[Category: Nucleotide binding domain]]
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[[Category: Substrate binding protein]]
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[[Category: Transmembrane integral membrane]]
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Current revision

Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3

PDB ID 3pux

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