3tw8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==GEF domain of DENND 1B in complex with Rab GTPase Rab35== | |
| + | <StructureSection load='3tw8' size='340' side='right'caption='[[3tw8]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tw8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TW8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tw8 OCA], [https://pdbe.org/3tw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tw8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DEN1B_HUMAN DEN1B_HUMAN] Guanine nucleotide exchange factor (GEF) for RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. May play a role in clathrin-mediated endocytosis.<ref>PMID:20154091</ref> <ref>PMID:20937701</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |
| - | + | *[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kummel D]] | ||
| + | [[Category: Reinisch KM]] | ||
| + | [[Category: Wu XD]] | ||
Current revision
GEF domain of DENND 1B in complex with Rab GTPase Rab35
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