2l3y

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[[Image:2l3y.jpg|left|200px]]
 
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==Solution structure of mouse IL-6==
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The line below this paragraph, containing "STRUCTURE_2l3y", creates the "Structure Box" on the page.
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<StructureSection load='2l3y' size='340' side='right'caption='[[2l3y]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 52 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [https://pdbe.org/2l3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [https://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>
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{{STRUCTURE_2l3y| PDB=2l3y | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A number of secreted cytokines, such as interleukin-6 (IL-6), are attractive targets for the treatment of inflammatory diseases. We have determined the solution structure of mouse IL-6 to assess the functional significance of apparent differences in the receptor interaction sites (IL-6Ralpha and gp130) suggested by the fairly low degree of sequence similarity with human IL-6. Structure-based sequence alignment of mouse IL-6 and human IL-6 revealed surprising differences in the conservation of the two distinct gp130 binding sites (IIa and IIIa), which suggests a primacy for site III-mediated interactions in driving initial assembly of the IL-6/IL-6Ralpha/gp130 ternary complex. This is further supported by a series of direct binding experiments, which clearly demonstrate a high affinity IL-6/IL-6Ralpha-gp130 interaction via site III but only weak binding via site II. Collectively, our findings suggest a pathway for the evolution of the hexameric, IL-6/IL-6Ralpha/gp130 signaling complex and strategies for therapeutic targeting. We propose that the signaling complex originally involved specific interactions between IL-6 and IL-6Ralpha (site I) and between the D1 domain of gp130 and IL-6/IL-6Ralpha (site III), with the later inclusion of interactions between the D2 and D3 domains of gp130 and IL-6/IL-6Ralpha (site II) through serendipity. It seems likely that IL-6 signaling benefited from the evolution of a multipurpose, nonspecific protein interaction surface on gp130, now known as the cytokine binding homology region (site II contact surface), which fortuitously contributes to stabilization of the IL-6/IL-6Ralpha/gp130 signaling complex.
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===Solution structure of mouse IL-6===
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Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.,Veverka V, Baker T, Redpath NT, Carrington B, Muskett FW, Taylor RJ, Lawson AD, Henry AJ, Carr MD J Biol Chem. 2012 Nov 16;287(47):40043-50. doi: 10.1074/jbc.M112.405597. Epub, 2012 Oct 1. PMID:23027872<ref>PMID:23027872</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l3y" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA].
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Carr, M D.]]
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[[Category: Carr MD]]
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[[Category: Carrington, B.]]
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[[Category: Carrington B]]
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[[Category: Henry, A J.]]
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[[Category: Henry AJ]]
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[[Category: Muskett, F W.]]
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[[Category: Muskett FW]]
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[[Category: Redpath, N T.]]
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[[Category: Redpath NT]]
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[[Category: Taylor, R J.]]
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[[Category: Taylor RJ]]
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[[Category: Veverka, V.]]
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[[Category: Veverka V]]
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[[Category: Cytokine]]
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[[Category: Gp-130]]
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[[Category: Interleukin]]
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[[Category: Signaling]]
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[[Category: Transcription]]
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Current revision

Solution structure of mouse IL-6

PDB ID 2l3y

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