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3nfb
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| - | [[Image:3nfb.jpg|left|200px]] | ||
| - | + | ==Crystal structure of the N-terminal beta-aminopeptidase BapA in complex with hydrolyzed ampicillin== | |
| - | + | <StructureSection load='3nfb' size='340' side='right'caption='[[3nfb]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3nfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingosinicella_xenopeptidilytica Sphingosinicella xenopeptidilytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |
| - | --> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OAE:(2S,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>OAE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfb OCA], [https://pdbe.org/3nfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfb RCSB], [https://www.ebi.ac.uk/pdbsum/3nfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfb ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BAPA_SPHXN BAPA_SPHXN] Beta-aminopeptidase that can cleave synthetic beta-peptides which consist of backbone-elongated beta-amino acid residues that are not processed by common proteolytic enzymes. Can cleave the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu. Requires a beta-amino acid at the N-terminus of peptide substrates and cleaves the peptide bond between the N-terminal beta-amino acid and the amino acid at the second position of tripeptidic substrates of the general structure H-betahXaa-Ile-betahTyr-OH according to the following preferences with regard to the side chain of the N-terminal beta-amino acid: aliphatic and aromatic > OH-containing > hydrogen, basic and polar.<ref>PMID:16109932</ref> <ref>PMID:17064315</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[ | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sphingosinicella xenopeptidilytica]] | [[Category: Sphingosinicella xenopeptidilytica]] | ||
| - | [[Category: Geueke | + | [[Category: Geueke B]] |
| - | [[Category: Gruetter | + | [[Category: Gruetter MG]] |
| - | [[Category: Heck | + | [[Category: Heck T]] |
| - | [[Category: Kohler | + | [[Category: Kohler H-PE]] |
| - | [[Category: Merz | + | [[Category: Merz T]] |
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Current revision
Crystal structure of the N-terminal beta-aminopeptidase BapA in complex with hydrolyzed ampicillin
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