3mk1

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[[Image:3mk1.png|left|200px]]
 
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==Refinement of placental alkaline phosphatase complexed with nitrophenyl==
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The line below this paragraph, containing "STRUCTURE_3mk1", creates the "Structure Box" on the page.
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<StructureSection load='3mk1' size='340' side='right'caption='[[3mk1]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mk1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MK1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NPO:P-NITROPHENOL'>NPO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3mk1| PDB=3mk1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mk1 OCA], [https://pdbe.org/3mk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mk1 RCSB], [https://www.ebi.ac.uk/pdbsum/3mk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mk1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPB1_HUMAN PPB1_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In order to gain deeper insights into the functional sites of human placental alkaline phosphatase, the structures of the enzyme with the putative regulators L-Phe, pNPP and 5'-AMP [Llinas et al. (2005), J. Mol. Biol. 350, 441-451] were re-refined. Significant variations in ligand positioning and identity were found compared with the previous report. The multiple corrections to the model improved the phases and the electron-density maps, allowing the modeling of omitted side chains and multiple disordered residues. These improvements led to a change in the position of L-Phe at the peripheral binding site, which appeared to be reversed. The structure with pNPP contained only p-nitrophenol in three distinct sites, while the structure with 5'-AMP contained the p-nitrophenyl group in two of the sites instead of 5'-AMP. Comparison of the re-refined models shows a consistent pattern of interactions at the peripheral site.
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===Refinement of placental alkaline phosphatase complexed with nitrophenyl===
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Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.,Stec B, Cheltsov A, Millan JL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt, 8):866-70. Epub 2010 Jul 27. PMID:20693656<ref>PMID:20693656</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3mk1" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15946677}}, adds the Publication Abstract to the page
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*[[Alkaline phosphatase 3D structures|Alkaline phosphatase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15946677 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15946677}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3mk1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK1 OCA].
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==Reference==
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<ref group="xtra">PMID:015946677</ref><ref group="xtra">PMID:020693656</ref><references group="xtra"/>
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[[Category: Alkaline phosphatase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cheltsov, A.]]
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[[Category: Large Structures]]
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[[Category: Millan, J L.]]
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[[Category: Cheltsov A]]
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[[Category: Stec, B.]]
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[[Category: Millan JL]]
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[[Category: Hydrolase]]
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[[Category: Stec B]]

Current revision

Refinement of placental alkaline phosphatase complexed with nitrophenyl

PDB ID 3mk1

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