3qzp

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[[Image:3qzp.png|left|200px]]
 
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==Staphylococcus aureus IsdA NEAT domain in complex with cobalt-protoporphyrin IX==
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The line below this paragraph, containing "STRUCTURE_3qzp", creates the "Structure Box" on the page.
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<StructureSection load='3qzp' size='340' side='right'caption='[[3qzp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qzp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qzp| PDB=3qzp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzp OCA], [https://pdbe.org/3qzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzp RCSB], [https://www.ebi.ac.uk/pdbsum/3qzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzp ProSAT]</span></td></tr>
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</table>
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===Staphylococcus aureus IsdA NEAT domain in complex with cobalt-protoporphyrin IX===
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== Function ==
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[https://www.uniprot.org/uniprot/ISDA_STAAN ISDA_STAAN] Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activated holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible. Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B-beta and gamma of fibrinogen. Could play a role in the removal of heme from hemoglobin. The IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. May function as a reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity).
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21893067}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21893067 is the PubMed ID number.
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[[Category: Staphylococcus aureus subsp. aureus N315]]
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[[Category: Grigg JC]]
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{{ABSTRACT_PUBMED_21893067}}
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[[Category: Mao CX]]
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[[Category: Murphy MEP]]
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==About this Structure==
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[[3qzp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZP OCA].
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==Reference==
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<ref group="xtra">PMID:021893067</ref><references group="xtra"/>
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[[Category: Staphylococcus aureus subsp. aureus]]
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[[Category: Grigg, J C.]]
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[[Category: Mao, C X.]]
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[[Category: Murphy, M E.P.]]
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[[Category: Cell wall]]
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[[Category: Heme]]
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[[Category: Iron]]
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[[Category: Metal binding protein]]
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[[Category: Receptor]]
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[[Category: Transport]]
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[[Category: Uptake]]
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Current revision

Staphylococcus aureus IsdA NEAT domain in complex with cobalt-protoporphyrin IX

PDB ID 3qzp

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