3toj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the SPRY domain of human Ash2L== | |
| + | <StructureSection load='3toj' size='340' side='right'caption='[[3toj]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3toj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TOJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3toj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3toj OCA], [https://pdbe.org/3toj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3toj RCSB], [https://www.ebi.ac.uk/pdbsum/3toj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3toj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cao F]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Dou Y]] | ||
| + | [[Category: Lei M]] | ||
| + | [[Category: Wan B]] | ||
Current revision
Structure of the SPRY domain of human Ash2L
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Categories: Homo sapiens | Large Structures | Cao F | Chen Y | Dou Y | Lei M | Wan B
