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3u0r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules== | |
| - | + | <StructureSection load='3u0r' size='340' side='right'caption='[[3u0r]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [https://pdbe.org/3u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [https://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cho JW]] | ||
| + | [[Category: Han BG]] | ||
| + | [[Category: Jeong KC]] | ||
| + | [[Category: Kim KH]] | ||
| + | [[Category: Kim TW]] | ||
| + | [[Category: Lee BI]] | ||
| + | [[Category: Lee SH]] | ||
| + | [[Category: Noh KH]] | ||
| + | [[Category: Suh SW]] | ||
| + | [[Category: Yoon HJ]] | ||
Current revision
Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules
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Categories: Homo sapiens | Large Structures | Cho JW | Han BG | Jeong KC | Kim KH | Kim TW | Lee BI | Lee SH | Noh KH | Suh SW | Yoon HJ
