3tyy

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[[Image:3tyy.jpg|left|200px]]
 
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==Crystal Structure of Human Lamin-B1 Coil 2 Segment==
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The line below this paragraph, containing "STRUCTURE_3tyy", creates the "Structure Box" on the page.
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<StructureSection load='3tyy' size='340' side='right'caption='[[3tyy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tyy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mov 3mov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TYY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.399&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tyy OCA], [https://pdbe.org/3tyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tyy RCSB], [https://www.ebi.ac.uk/pdbsum/3tyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tyy ProSAT]</span></td></tr>
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{{STRUCTURE_3tyy| PDB=3tyy | SCENE= }}
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</table>
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== Disease ==
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===Crystal Structure of Human Lamin-B1 Coil 2 Segment===
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[https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[https://omim.org/entry/169500 169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
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==About this Structure==
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== References ==
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[[3tyy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mov 3mov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYY OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bian, C B.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bian CB]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Lam, R.]]
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[[Category: Edwards AM]]
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[[Category: Mackenzie, F.]]
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[[Category: Lam R]]
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[[Category: Min, J.]]
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[[Category: Mackenzie F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: B-type lamin]]
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[[Category: Lamin-b1]]
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[[Category: Lmnb1]]
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[[Category: Membrane]]
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[[Category: Nucleus]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Structural protein]]
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Current revision

Crystal Structure of Human Lamin-B1 Coil 2 Segment

PDB ID 3tyy

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