3ryc

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[[Image:3ryc.jpg|left|200px]]
 
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==Tubulin: RB3 stathmin-like domain complex==
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The line below this paragraph, containing "STRUCTURE_3ryc", creates the "Structure Box" on the page.
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<StructureSection load='3ryc' size='340' side='right'caption='[[3ryc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ryc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RYC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ryc| PDB=3ryc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ryc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ryc OCA], [https://pdbe.org/3ryc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ryc RCSB], [https://www.ebi.ac.uk/pdbsum/3ryc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ryc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tubulin alternates between a soluble curved structure and a microtubule straight conformation. GTP binding to alphabeta-tubulin is required for microtubule assembly, but whether this triggers conversion into a straighter structure is still debated. This is due, at least in part, to the lack of structural data for GTP-tubulin before assembly. Here, we report atomic-resolution crystal structures of soluble tubulin in the GDP and GTP nucleotide states in a complex with a stathmin-like domain. The structures differ locally in the neighborhood of the nucleotide. A loop movement in GTP-bound tubulin favors its recruitment to the ends of growing microtubules and facilitates its curved-to-straight transition, but this conversion has not proceeded yet. The data therefore argue for the conformational change toward the straight structure occurring as microtubule-specific contacts are established. They also suggest a model for the way the tubulin structure is modified in relation to microtubule assembly.
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===Tubulin: RB3 stathmin-like domain complex===
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The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin.,Nawrotek A, Knossow M, Gigant B J Mol Biol. 2011 Sep 9;412(1):35-42. Epub 2011 Jul 23. PMID:21787788<ref>PMID:21787788</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ryc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21787788}}, adds the Publication Abstract to the page
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*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21787788 is the PubMed ID number.
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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== References ==
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{{ABSTRACT_PUBMED_21787788}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3ryc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RYC OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:021787788</ref><references group="xtra"/>
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[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Gigant, B.]]
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[[Category: Gigant B]]
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[[Category: Knossow, M.]]
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[[Category: Knossow M]]
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[[Category: Nawrotek, A.]]
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[[Category: Nawrotek A]]
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[[Category: Alpha-tubulin]]
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[[Category: Beta-tubulin]]
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[[Category: Cell cycle]]
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[[Category: Gtpase]]
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[[Category: Microtubule]]
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[[Category: Stathmin s-tubulin]]
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[[Category: Subtilisin]]
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[[Category: Tubulin]]
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Current revision

Tubulin: RB3 stathmin-like domain complex

PDB ID 3ryc

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