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3aon

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[[Image:3aon.jpg|left|200px]]
 
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==Crystal structure of the central axis (NtpD-NtpG) in the catalytic portion of Enterococcus hirae V-type sodium ATPase==
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The line below this paragraph, containing "STRUCTURE_3aon", creates the "Structure Box" on the page.
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<StructureSection load='3aon' size='340' side='right'caption='[[3aon]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3aon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AON FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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{{STRUCTURE_3aon| PDB=3aon | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aon OCA], [https://pdbe.org/3aon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aon RCSB], [https://www.ebi.ac.uk/pdbsum/3aon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aon ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NTPD_ENTHA NTPD_ENTHA] Involved in ATP-driven sodium extrusion.<ref>PMID:8157629</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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V-ATPases function as ATP-dependent ion pumps in various membrane systems of living organisms. ATP hydrolysis causes rotation of the central rotor complex, which is composed of the central axis D subunit and a membrane c ring that are connected by F and d subunits. Here we determined the crystal structure of the DF complex of the prokaryotic V-ATPase of Enterococcus hirae at 2.0-A resolution. The structure of the D subunit comprised a long left-handed coiled coil with a unique short beta-hairpin region that is effective in stimulating the ATPase activity of V(1)-ATPase by twofold. The F subunit is bound to the middle portion of the D subunit. The C-terminal helix of the F subunit, which was believed to function as a regulatory region by extending into the catalytic A(3)B(3) complex, contributes to tight binding to the D subunit by forming a three-helix bundle. Both D and F subunits are necessary to bind the d subunit that links to the c ring. From these findings, we modeled the entire rotor complex (DFdc ring) of V-ATPase.
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===Crystal structure of the central axis (NtpD-NtpG) in the catalytic portion of Enterococcus hirae V-type sodium ATPase===
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Crystal structure of the central axis DF complex of the prokaryotic V-ATPase.,Saijo S, Arai S, Hossain KM, Yamato I, Suzuki K, Kakinuma Y, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Murata T Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19955-60. Epub 2011 Nov 23. PMID:22114184<ref>PMID:22114184</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3aon" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3aon]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_hirae Enterococcus hirae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AON OCA].
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Enterococcus hirae]]
[[Category: Enterococcus hirae]]
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[[Category: Arai, S.]]
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[[Category: Large Structures]]
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[[Category: Hossain, K M.M.]]
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[[Category: Arai S]]
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[[Category: Ishizuka-Katsura, Y.]]
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[[Category: Hossain KMM]]
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[[Category: Iwata, S.]]
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[[Category: Ishizuka-Katsura Y]]
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[[Category: Kakinuma, Y.]]
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[[Category: Iwata S]]
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[[Category: Murata, T.]]
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[[Category: Kakinuma Y]]
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[[Category: Saijo, S.]]
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[[Category: Murata T]]
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[[Category: Shirouzu, M.]]
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[[Category: Saijo S]]
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[[Category: Terada, T.]]
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[[Category: Shirouzu M]]
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[[Category: Yamato, I.]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yamato I]]
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[[Category: Alpha/beta fold]]
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[[Category: Yokoyama S]]
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[[Category: Central axis]]
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[[Category: Coiled-coil]]
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[[Category: Enterococcus]]
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[[Category: Hydrolase]]
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[[Category: Ntpa3-ntpb3]]
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[[Category: Ntpc]]
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[[Category: V-atpase]]
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Current revision

Crystal structure of the central axis (NtpD-NtpG) in the catalytic portion of Enterococcus hirae V-type sodium ATPase

PDB ID 3aon

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