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3tql

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[[Image:3tql.jpg|left|200px]]
 
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==Structure of the amino acid ABC transporter, periplasmic amino acid-binding protein from Coxiella burnetii.==
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The line below this paragraph, containing "STRUCTURE_3tql", creates the "Structure Box" on the page.
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<StructureSection load='3tql' size='340' side='right'caption='[[3tql]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"rickettsia_burneti"_(sic)_derrick_1939 "rickettsia burneti" (sic) derrick 1939]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3tql| PDB=3tql | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBU_0482 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=777 "Rickettsia burneti" (sic) Derrick 1939])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tql OCA], [https://pdbe.org/3tql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tql RCSB], [https://www.ebi.ac.uk/pdbsum/3tql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tql ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coxiella burnetii is a highly infectious bacterium and potential agent of bioterrorism. However, it has not been studied as extensively as other biological agents, and very few of its proteins have been structurally characterized. To address this situation, we undertook a study of critical metabolic enzymes in C. burnetii that have great potential as drug targets. We used high-throughput techniques to produce novel crystal structures of 48 of these proteins. We selected one protein, C. burnetii dihydrofolate reductase (CbDHFR), for additional work to demonstrate the value of these structures for structure-based drug design. This enzyme's structure reveals a feature in the substrate binding groove that is different between CbDHFR and human dihydrofolate reductase (hDFHR). We then identified a compound by in silico screening that exploits this binding groove difference, and demonstrated that this compound inhibits CbDHFR with at least 25-fold greater potency than hDHFR. Since this binding groove feature is shared by many other prokaryotes, the compound identified could form the basis of a novel antibacterial agent effective against a broad spectrum of pathogenic bacteria. This article is protected by copyright. All rights reserved.
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===Structure of the amino acid ABC transporter, periplasmic amino acid-binding protein from Coxiella burnetii.===
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Structural Genomics for Drug Design against the Pathogen Coxiella burnetii.,Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD Proteins. 2015 Jun 1. doi: 10.1002/prot.24841. PMID:26033498<ref>PMID:26033498</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tql" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3tql]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxiella_burnetii Coxiella burnetii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQL OCA].
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*[[ABC transporter|ABC transporter]]
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[[Category: Coxiella burnetii]]
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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[[Category: Burshteyn, F.]]
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== References ==
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[[Category: Cassidy, M.]]
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<references/>
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[[Category: Cheung, J.]]
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__TOC__
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[[Category: Franklin, M.]]
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</StructureSection>
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[[Category: Gary, E.]]
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[[Category: Large Structures]]
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[[Category: Love, J.]]
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[[Category: Burshteyn, F]]
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[[Category: Rudolph, M.]]
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[[Category: Cassidy, M]]
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[[Category: Cheung, J]]
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[[Category: Franklin, M C]]
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[[Category: Gary, E]]
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[[Category: Love, J]]
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[[Category: Rudolph, M]]
[[Category: Transport and binding protein]]
[[Category: Transport and binding protein]]
[[Category: Transport protein]]
[[Category: Transport protein]]

Current revision

Structure of the amino acid ABC transporter, periplasmic amino acid-binding protein from Coxiella burnetii.

PDB ID 3tql

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