This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Neuropilin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:21, 16 July 2023) (edit) (undo)
 
(20 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ion, [[2qqm]] }}
+
<StructureSection load='' size='350' side='right' scene='46/466529/Cv/1' caption='Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) [[2qqm]]'>
-
+
-
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A while NRP-2 has high affinity for semaphorin-3F.
+
-
{{TOC limit|limit=2}}
+
== Function ==
 +
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br />
 +
* '''NRP-1''' has high affinity for semaphorin-3A.<br />
 +
* '''NRP-2''' has high affinity for semaphorin-3F.
 +
== Relevance ==
 +
NRP are highly expressed in human neoplasms<ref>PMID:18363553</ref>.
 +
 +
== Structural highlights ==
 +
NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region.
 +
*<scene name='46/466529/Cv/3'>Ca coordination site</scene>. Water molecule are shown as red sphere.
 +
</StructureSection>
== 3D Structures of Neuropilin ==
== 3D Structures of Neuropilin ==
-
===NRP-1===
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
[[1kex]], [[2qqi]] – hNRP-1 B domain – human
+
*NRP-1; Domains - B1 273-427, MAM 628-813, A2B1B2 141-586
-
[[2qqm]] - hNRP-1 A+B domain
+
**[[1kex]], [[2qqi]] – hNRP-1 B1 domain – human<br />
 +
**[[4rn5]] – hNRP-1 B1 domain<br />
 +
**[[7o1n]] – hNRP-1 B1 domain (mutant)<br />
 +
**[[5l73]] – hNRP-1 MAM domain<br />
 +
**[[2qqm]] - hNRP-1 A2+B1+B2 domains<br />
 +
**[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br />
 +
**[[6tkk]] - hNRP-1 B1 domain + VEGF-A peptide<br />
 +
**[[7p5u]] - hNRP-1 B1 domain + VEGF-B peptide<br />
 +
**[[7jjc]] - hNRP-1 B1 domain + SARS-CoV-2 peptide<br />
 +
**[[2qqn]] - hNRP-1 B1 domain + VEGF-blocking antibody
 +
**[[5c7g]] – hNRP-1 B1 domain + bicine<br />
 +
**[[5ijr]], [[5iyy]], [[5j1x]], [[5jgi]], [[5jgq]], [[5jhk]] – hNRP-1 B1 domain + arginine derivative<br />
 +
**[[3i97]], [[6fmc]], [[6fmf]] - hNRP-1 B1 domains + inhibitor
-
[[2qqn]] - hNRP-1 B domain + VEGF-blocking antibody
+
**[[2orx]] – rNRP-1 B domains – rat
-
[[3i97]] - hNRP-1 B domains + inhibitor
+
**[[2orz]] – rNRP-1 B domains + tuftsin peptide<br />
 +
**[[4gz9]] - mNRP-1 – mouse<br />
 +
**[[4gza]] - mNRP-1 + plexin A2 + semaphorin 3A<br />
 +
**[[7m0r]] – mNRP-1 + Semaphorin 3A + plexin A4 – Cryo EM<br />
-
[[2orx]] – rNRP-1 C1+C2 domains – rat
+
*NRP-2; Domains - CUB 27-145; A2 145-275; B1 275-430; B2 431-595
-
[[2orz]] – rNRP-1 + tuftsin peptide
+
**[[7t4s]] – hNRP-2 + Herpes virus envelope + antibody – Cryo EM<br />
-
 
+
**[[4qdq]], [[4qds]], [[2qqj]] - hNRP-2 B1+B2 domains<br />
-
===NRP-2===
+
**[[5dq0]] – hNRP-2 B1 domain<br />
-
 
+
**[[4qdr]] - hNRP-2 B1+B2 domain (mutant)<br />
-
[[2qqj]] - hNRP-2 B domain
+
**[[2qqo]] - hNRP-2 A2+B1+B2 domains
-
 
+
-
[[2qqo]] - hNRP-2 A+B domains
+
-
[[2qqk]], [[2qql]] - hNRP-2 A+B domains + semaphorin-blocking antibody
+
**[[2qqk]], [[2qql]] - hNRP-2 A2+B1+B2 domains + semaphorin-blocking antibody<br />
-
 
+
**[[5dn2]], [[6tdb]], [[6tjt]] – hNRP-2 B1 domain + VEGF-A C terminal<br />
 +
**[[6gh8]] – hNRP-2 CUB domain 1 + Gp1<br />
 +
**[[7m22]] – mNRP-2 + cytomegalovirus – Cryo EM<br />
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) 2qqm

Drag the structure with the mouse to rotate

3D Structures of Neuropilin

Updated on 16-July-2023

References

  1. ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
  2. ↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:http://dx.doi.org/10.1042/BJ20071639

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Neuropilin"
Personal tools