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3q72

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[[Image:3q72.png|left|200px]]
 
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==Crystal Structure of Rad G-domain-GTP Analog Complex==
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The line below this paragraph, containing "STRUCTURE_3q72", creates the "Structure Box" on the page.
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<StructureSection load='3q72' size='340' side='right'caption='[[3q72]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q72 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.655&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3q72| PDB=3q72 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q72 OCA], [https://pdbe.org/3q72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q72 RCSB], [https://www.ebi.ac.uk/pdbsum/3q72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q72 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref>
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===Crystal Structure of Rad G-domain-GTP Analog Complex===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21903096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21903096}}
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==About this Structure==
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[[3q72]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q72 OCA].
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==Reference==
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<ref group="xtra">PMID:021903096</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hirsch, J A.]]
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[[Category: Large Structures]]
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[[Category: Navon-Perry, L.]]
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[[Category: Hirsch JA]]
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[[Category: Sasson, Y.]]
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[[Category: Navon-Perry L]]
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[[Category: Cav2 beta]]
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[[Category: Sasson Y]]
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[[Category: G-domain]]
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[[Category: G-protein]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Rad G-domain-GTP Analog Complex

PDB ID 3q72

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OCA

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